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Technical Information & Research

The Technical Information & Research section provides extensive materials on LabDiet® phytoestrogen research and diets, nutrient & contaminant levels in LabDiet® certified diets, specie intake and biological data, certified analysis technical data and bibliography search data around LabDiet products.


  • PHYTOESTROGRENS

    THE FACTS ABOUT ISOFLAVONES: A LOOK AT THE BIG PICTURE

    Isoflavones, the most common form of phytoestrogens, are detectable in most all diets fed to laboratory animals. Isoflavones are not bad for animals; however more and more researchers need to verify the levels contained in the diets for specific study area. Before making your decision about isoflavones, there is more that you should know.

    FACTS ON ISOFLAVONES IN DIETS

    Click the link below to find information to assist you in making the correct choice for your lab animals.

    • Isoflavones (IF) are a common class of phytoestrogens. They are plant-derived compounds capable of estrogenic or antiestrogenic effects on the animals consuming them. Isoflavones are structural mimics of endogenous 17ß-estradiol (Seielstad, et al., 1995).
    • IFs are nothing new. As early as the 1920s, IFs were found to affect body metabolism and in the 1940s, IFs found in red clover were found to affect sheep fertility.
    • Since the early 1990s, with an increase in endocrine disruptor (ED) awareness, IFs have been identified as contributing factors that may affect the outcome of such studies.
    • In the lab community, some advocate feeding low IF diets to all of their animals. However, others feel the low IF diets should only be used where appropriate.
    THE FACTS ABOUT ISOFLAVONES: A LOOK AT THE BIG PICTURE
  • NUTRIENT & CONTAMINENT LEVELS

    Nutrient and Contamination Levels in LabDiet® Certified Laboratory Animal Feeds

    Based on data compiled from 1993-2012 by Purina LabDiet® and in conjunction with an independent laboratory.

    Animal diets used in laboratory studies must provide consistent and proper nutrition.1  To assist in experimental control, feed manufacturers must ensure that all batches of feed meet approved nutritional profiles.2  Certified diets for laboratory animals are commonly used in toxicological studies where control of contaminants, such as pesticides and heavy metals, is imperative.  Certified LabDiet® products manufactured by PMI are analyzed prior to sale and guaranteed not to exceed established maximum concentrations of key contaminants.  PMI controls variables that could adversely affect study animals and possibly lead to inaccurate conclusions.  Certified LabDiet® products meet the recommendations of the FDA's Good Laboratory Practices Program.

    This report is an update to our 2007 published bulletin "Nutrient and Contaminant Levels in LabDiet® Certified Laboratory Animal Feeds: 15-Year Technical Bulletin" which reports the results of our ongoing efforts to provide diets that are consistent from batch to batch as well as year to year.  The data reported in this bulletin includes that from 1993 to 2007 and now 2008 to 2012. 

    20-YEAR TECHNICAL BULLETIN UPDATE 
  • INTAKE & BIOLOGICAL DATA
    Rats
    Mice
    Hamsters
    Guinea Pigs
    Rabbits
    Non-Human Primates
    Canines
    Feline
    Ferrets
    Laboratory Swine
    Ruminants
    Poultry
  • TECHNICAL UPDATES

    The LabDiet® Technical Updates contains the following analysis:

    • Microbiology Report
    • Summary of Nutritional Analyses
    • Contaminants Report


    Related Documents

  • PUBLICATIONS