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Advanced Protocol®
ADVANCED PROTOCOL® FROM LABDIET®
We're Advancing with You.
At Purina Mills (PMI®), there's nothing we value more than the trust of the research community. Cultivated over more than 60 years, it's a legacy unmatched in the industry. Today, the legacy continues --- with Advanced Protocol®.
Advanced Protocol® is a new line of diet options for new directions in research. It's designed to give scientists conducting today's targeted studies all the advantages of using a proven LabDiet® product.
YOUR WORK IS WORTH IT
Since 1942, LabDiet® has been the leader in research animal nutrition. Through countless studies and innumerable scientific advances, researchers have trusted LabDiet® for consistent, credible results more than any other brand. As the frontiers of science have advanced, so have we, pioneering such breakthroughs as irradiated diets, portion control feeding, customized TestDiet® products, and more. Through it all, one principle has remained constant: that the work of science is too important to risk on diets unproven by science.
The methods of scientific research are always evolving. But changes in recent years have been dramatic, including the advent of new animal models and expanded knowledge of nutrients and non-nutrients. Research has become significantly more precise and targeted. In order to maintain the control you've come to expect from LabDiet®, we recognized that a specialized line of advanced diet options was needed.
LAB RESEARCH COMBINED WITH MARKET RESEARCH
Working in concert with researchers at universities and other leading facilities across the country, scientists at our Gray Summit Research Center began the work that would lead to Advanced Protocol® over a decade ago. They tested. Investigated. Refined. They sought to define key variables, such as the level of nutrients and the effects of non-nutrients required to optimize animal performance while maintaining study parameters. Only when conclusive results were gathered did we create Advanced Protocol™ products. The result is a targeted line that's based, as are all LabDiet® products, on solid science, not whim.
We created Advanced Protocol® to give you advanced dietary options for new directions in today's research. Of the 27 products in the line, 9 are for rodent models. Others are for a variety of other research animals in use today, including birds, fish, and frogs. For rodent studies requiring diets with exact levels of isoflavones, 5 products are available with verified low isoflavone levels.
LABDIET®: SETTING THE STANDARD FOR OVER 60 YEARS
1917 Purina Research Center established in Gray Summit, Missouri
1930s Purina begins investigating the unique dietary needs of laboratory animal
1942 LabDiet® 5001 Rodent Diet introduced --- first diet specifically formulated for laboratory research animals
1960 Complete nutritional information published for all LabDiet products
1970s Certified LabDiet® introduced --- first to comply with GLP standards
1984 PicoLab® introduced --- first irradiated diets
1996 Richmond plant achieves industry's first ISO certification
1997 A new TestDiet® custom diet facility is built, achieves ISO certification
1998 Micro-Pack™ Portion Control introduced
1999 DentaGuard introduced --- first additive to prevent dental calculus
2003 LabDiet® Advanced Protocol® introduced
2004 LabDiet® becomes the first Titanium Corporate Sponsor of
The
Jackson Laboratory
2006 TestDiet® opens manufacturing site in the United Kingdom
2007 TestDiet® expands tablet production; introduces Primate
Enrichment and Helaht Products
THE NAME YOU TRUST
When you choose Advanced Protocol® products, you get legendary LabDiet® quality through and through. And that means:
• Constant Nutrition®. Our exclusive formulation program assures you of constant levels of nutrients in every product you buy. And when consistent diets go into your research, precise results come out.
• ISO 9001:2000 certification. Our plant in Richmond, Indiana, meets the uncompromising quality management requirements of the International Standards Organization --- the only laboratory animal food plant in North America that does. Our high standards mean that you have better control over your research.
• LabDiet® scientists. Partners who can understand your research and help you choose the best product --- whether it's an Advanced Protocol® diet or another LabDiet® product --- are always just a phone call away.
• Over 60 years of leadership. Since 1942, we've supported the best scientific research with the best research-proven animal nutrition products.
What it all means is this: LabDiet® Advanced Protocol® gives you the same level of confidence that you've always gotten from PMI® products. Confidence that even your most targeted research will never be compromised by unproven diets.
With LabDiet®, we've always said, "Your work is worth it." With Advanced Protocol®, your work is still worth it. Now more than ever.
DIET OPTIONS FOR TRANSGENICS
There's a LabDiet® product for every lab animal need
Based on research done at Purina Mills and collaborative laboratories, and feedback from our customers, we offer the following guidelines for feeding transgenic rodents:
• If you've had success using a standard LabDiet® product, we recommend that no changes be made to your feeding regimen.
• For protocols in which estrogen activity needs to be monitored and managed, refer to our new Advanced Protocol® verified rodent diets. There are
several diets from which to select.
• For protocols in which estrogen activity doesn't need to be monitored, refer to
our standard LabDiet® products.
• For protocols that require intensive, postpartum breeding of mice, PicoLab® 5058 or PicoLab® 5LJ5 is recommended. Both products are high-fat diets designed to provide the proper nutrition for challenging breeding pairs. Vacuum-packed options are also available.
• For protocols that require less intensive rodent breeding or just good, sound animal maintenance, PicoLab® 5053,
JL Rat and Mouse/Auto 6F 5K67, JL Rat and Mouse/Irr
6F 5LG4, or Prolab® Isopro® RMH 3000 5P76 works best.
• Ask for a copy of our "21st Century Nutrition Brochure," a complete list of
the world's most widely used diets for today's
transgenic models, including the JL series of diets.
Since 1982, when a team led by Richard Palmiter and Ralph Brinster injected modified rat DNA into a fertilized mouse embryo, thousands of transgenic strains have been developed. Transgenics have enriched the landscape of genetic diversification, which already included crossbreeding, inbreeding, and selection of mutants. And researchers from PMI® have led the way in understanding transgenics' diverse nutritional needs.
No single diet is right for every transgenic mouse. If the transgenic has been developed on an inbred mouse background, for example, its needs will likely be the same as the inbred's. On the other hand, transgenics that model cancer tumors or cardiovascular disease, or are sensitive to exogenous estrogen sources, may need a low-isoflavone diet.
Whether your study uses transgenics or not, there's a LabDiet® product that will lead you to results you can believe in, every time. A LabDiet® scientist can help you choose --- just
email us at
info@labdiet.com.
Advanced Protocol® Verified Diets
Advanced Protocol® verified rodent diets are formulated for rat and mouse colonies that require management of dietary estrogenic activity. They are manufactured at the PMI® ISO 9001:2000 plant in Richmond, Indiana. Each production batch is sampled and analyzed for total isoflavone content (genistein, daidzein, and glycitein) prior to release for sale.
Verified rodent diets are guaranteed to contain no more than 50 ppm, 75 ppm or 150 ppm total isoflavones, depending on the product.
If your study requires a diet with controlled, measured, and verified levels of isoflavones, the chart below can help you choose the correct one. Or
email a LabDiet® scientist at
info@labdiet.com.
Product Number Product Name
5K96 Advanced Protocol® Verified Casein Diet 10 IF
5V00 Advanced Protocol® Verified 50 IF
5V01 Advanced Protocol® Verified 150 IF
5V02 Advanced Protocol® Verified PicoLab® Rodent 50 IF
5V03 Advanced Protocol® Verified PicoLab® Mouse 50 IF
5V75 Advanced Protocol® Verified - 75
IF
Symbol Key:
ND Not Determined
Tg Transgenic
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